Deoxycholateinduces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C
Document Type
Article
Date of Publication
6-14-1985
Publication Title
Biochemical and Biophysical Research Communications
First Page
411
Last Page
436
Abstract
Deoxycholate promotes phospholipase C degradation of endogenous phosphatidyl[3H]inositol (PI), phosphatidyl[3H]inositol monophosphate (PIP) and phosphatidyl[3H]inositol bisphosphate (PIP2) in rat cornea and human platelets. Hydrolysis of phosphatidyl[3H]inositol significantly lags polyphospho[3H]inositide degradation. Concomitantly, formation of [3H]inositol monophosphate (IP1) lags behind [3H]inositol bisphosphate (IP2) and [3H]inositol trisphosphate (IP3) production. These results demonstrate that rat cornea and human platelet phospholipase C cause a preferential hydrolysis of the endogenous polyphosphoinositides rather than phosphatidylinositol.
DOI
https://doi.org/10.1016/0006-291X(85)90166-4
Recommended Citation
Chung, S. M.; Proia, A. D.; Klintworth, G. K.; Watson, S. P.; and Lapetina, E. G., "Deoxycholateinduces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C" (1985). Osteopathic Medicine, Jerry M. Wallace School of. 520.
https://cufind.campbell.edu/medicine_school/520
