Role of Peroxiredoxins in Protecting Against Cardiovascular and Related Disorders

Authors

Y R. Li, Department of Pharmacology, Campbell University Jerry Wallace School of Osteopathic Medicine, Buies Creek, NC, 27506, USA. yli@campbell.edu.
Hong Zhu, Department of Physiology and Pathophysiology, Campbell University School of Osteopathic Medicine, Buies Creek, NC, 27506, USA.
Igor Danelisen, Department of Medical Education, Tufts University School of Medicine, Boston, MA, 02111, USA.

Document Type

Article

Date of Publication

10-1-2020

Publication Title

Cardiovascular toxicology

First Page

448

Last Page

453

Abstract

Peroxiredoxin (Prx) refers to a family of thiol-dependent peroxidases that decompose hydrogen peroxide, lipid hydroperoxides, as well as peroxynitrite, and protect against oxidative and inflammatory stress. There are six mammalian Prx isozymes (Prx1-6), classified as typical 2-Cys, atypical 2-Cys, or 1-Cys Prxs based on the mechanism and the number of cysteine residues involved during catalysis. In addition to their well-established peroxide-scavenging activity, some Prxs also participate in the regulation of various cell signaling pathways. Extensive animal studies employing primarily gene knockout models provide substantial evidence supporting a critical protective role of Prxs in various disease processes involving oxidative and inflammatory stress. This review surveys recent research findings, published primarily in influential journals, on the involvement of various Prx isozymes in protecting against cardiovascular injury and related disorders, including diabetes, metabolic syndromes, and sepsis, whose pathophysiology all intimately involves oxidative stress and inflammation.

DOI

10.1007/s12012-020-09588-0

Recommended Citation

Li, Y R.; Zhu, Hong; and Danelisen, Igor, "Role of Peroxiredoxins in Protecting Against Cardiovascular and Related Disorders" (2020). Osteopathic Medicine, Jerry M. Wallace School of. 2394.
https://cufind.campbell.edu/medicine_school/2394