Molecular mechanisms of action of metformin: latest advances and therapeutic implications

Authors

Hong Zhu, Department of Physiology and Pathophysiology, Jerry M. Wallace School of Osteopathic Medicine, Campbell University SOM, Buies Creek, NC, USA. zhu@campbell.edu.
Zhenquan Jia, Department of Biology, College of Arts and Sciences, University of North Carolina, Greensboro, NC, USA.
Y R. Li, Department of Pharmacology, Jerry M. Wallace School of Osteopathic Medicine, Campbell University, Buies Creek, NC, USA.
Igor Danelisen, Geisinger Commonwealth School of Medicine, Scranton, PA, USA.

Document Type

Article

Date of Publication

11-1-2023

Publication Title

Clinical and experimental medicine

First Page

2941

Last Page

2951

Abstract

Metformin is among the most widely used antidiabetic drugs. Studies over the past few years have identified multiple novel molecular targets and pathways that metformin acts on to exert its beneficial effects in treating type 2 diabetes as well as other disorders involving dysregulated inflammation and redox homeostasis. In this mini-review, we discuss the latest cutting-edge research discoveries on novel molecular targets of metformin in glycemic control, cardiovascular protection, cancer intervention, anti-inflammation, antiaging, and weight control. Identification of these novel targets and pathways not only deepens our understanding of the molecular mechanisms by which metformin exerts diverse beneficial biological effects, but also provides opportunities for developing new mechanistically based drugs for human diseases.

DOI

10.1007/s10238-023-01051-y

Recommended Citation

Zhu, Hong; Jia, Zhenquan; Li, Y R.; and Danelisen, Igor, "Molecular mechanisms of action of metformin: latest advances and therapeutic implications" (2023). Osteopathic Medicine, Jerry M. Wallace School of. 2385.
https://cufind.campbell.edu/medicine_school/2385