Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,,4-diamino-7-aminoalkoxy-quinazolines

F. Liu; X. Chen; A. A. Hassani; A. M. Quinn; T. J. Wigle; G. A. Wasney; A. Dong; D. Barsyte; I. Kozieradzki; G. Senisterra; I. Chau; A. Siarheyeva; A. V. Deusen; D. B. Kireev; D. T. Pohlhaus; A. Jadhav; J. M. Herold; S. V. Frye; C. H. Arrowsmith; P. J. Brown; A. Simeonov; M. Vedadi; J. Jin

doi:10.1021/jm100478y

Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,,4-diamino-7-aminoalkoxy-quinazolines

F. Liu
, X. Chen
, A. A. Hassani
, A. M. Quinn
, T. J. Wigle
, G. A. Wasney
, A. Dong
, D. Barsyte
, I. Kozieradzki
, G. Senisterra
, I. Chau
, A. Siarheyeva
, A. V. Deusen
, D. B. Kireev
, D. T. Pohlhaus
, A. Jadhav
, J. M. Herold
, S. V. Frye
, C. H. Arrowsmith
, P. J. Brown

A. Simeonov, M. Vedadi, J. Jin

Campbell University

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Journal of Medicinal Chemistry
Volume	53
DOIs	https://doi.org/10.1021/jm100478y
State	Published - Jan 1 2010

Disciplines

Pharmacy and Pharmaceutical Sciences

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https://pubmed.ncbi.nlm.nih.gov/20614940/

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Liu, F., Chen, X., Hassani, A. A., Quinn, A. M., Wigle, T. J., Wasney, G. A., Dong, A., Barsyte, D., Kozieradzki, I., Senisterra, G., Chau, I., Siarheyeva, A., Deusen, A. V., Kireev, D. B., Pohlhaus, D. T., Jadhav, A., Herold, J. M., Frye, S. V., Arrowsmith, C. H., ... Jin, J. (2010). Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,,4-diamino-7-aminoalkoxy-quinazolines. Journal of Medicinal Chemistry, 53. https://doi.org/10.1021/jm100478y

Liu, F, Chen, X, Hassani, AA, Quinn, AM, Wigle, TJ, Wasney, GA, Dong, A, Barsyte, D, Kozieradzki, I, Senisterra, G, Chau, I, Siarheyeva, A, Deusen, AV, Kireev, DB, Pohlhaus, DT, Jadhav, A, Herold, JM, Frye, SV, Arrowsmith, CH, Brown, PJ, Simeonov, A, Vedadi, M & Jin, J 2010, 'Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,,4-diamino-7-aminoalkoxy-quinazolines', Journal of Medicinal Chemistry, vol. 53. https://doi.org/10.1021/jm100478y

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title = "Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,,4-diamino-7-aminoalkoxy-quinazolines",

author = "F. Liu and X. Chen and Hassani, \{A. A.\} and Quinn, \{A. M.\} and Wigle, \{T. J.\} and Wasney, \{G. A.\} and A. Dong and D. Barsyte and I. Kozieradzki and G. Senisterra and I. Chau and A. Siarheyeva and Deusen, \{A. V.\} and Kireev, \{D. B.\} and Pohlhaus, \{D. T.\} and A. Jadhav and Herold, \{J. M.\} and Frye, \{S. V.\} and Arrowsmith, \{C. H.\} and Brown, \{P. J.\} and A. Simeonov and M. Vedadi and J. Jin",

year = "2010",

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day = "1",

doi = "10.1021/jm100478y",

language = "American English",

volume = "53",

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TY - JOUR

T1 - Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,,4-diamino-7-aminoalkoxy-quinazolines

AU - Liu, F.

AU - Chen, X.

AU - Hassani, A. A.

AU - Quinn, A. M.

AU - Wigle, T. J.

AU - Wasney, G. A.

AU - Dong, A.

AU - Barsyte, D.

AU - Kozieradzki, I.

AU - Senisterra, G.

AU - Chau, I.

AU - Siarheyeva, A.

AU - Deusen, A. V.

AU - Kireev, D. B.

AU - Pohlhaus, D. T.

AU - Jadhav, A.

AU - Herold, J. M.

AU - Frye, S. V.

AU - Arrowsmith, C. H.

AU - Brown, P. J.

AU - Simeonov, A.

AU - Vedadi, M.

AU - Jin, J.

PY - 2010/1/1

Y1 - 2010/1/1

UR - https://cufind.campbell.edu/pharmacy/2313

UR - https://pubmed.ncbi.nlm.nih.gov/20614940/

U2 - 10.1021/jm100478y

DO - 10.1021/jm100478y

M3 - Article

VL - 53

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

ER -

Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,,4-diamino-7-aminoalkoxy-quinazolines

Disciplines

Access to Document

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