Discovery of a 2,4-Diamino-7-aminoalkoxy-quinazoline as a potent, selective, and cellularly active inhibitor of histone lysine methyltransferase G9a

F. Liu; X. Chen; A. A. Hassani; A. M. Quinn; G. A. Wasney; A. Dong; D. Barsyte; I. Kozieradzki; G. Senisterra; I. Chau; D. B. Kireev; A. Jadhav; J. M. Herold; S. V. Frye; C. H. Arrowsmith; P. J. Brown; A. Simeonov; M. Vedadi; J. Jin

doi:10.1021/jm901543m

Discovery of a 2,4-Diamino-7-aminoalkoxy-quinazoline as a potent, selective, and cellularly active inhibitor of histone lysine methyltransferase G9a

F. Liu
, X. Chen
, A. A. Hassani
, A. M. Quinn
, G. A. Wasney
, A. Dong
, D. Barsyte
, I. Kozieradzki
, G. Senisterra
, I. Chau
, D. B. Kireev
, A. Jadhav
, J. M. Herold
, S. V. Frye
, C. H. Arrowsmith
, P. J. Brown
, A. Simeonov
, M. Vedadi
, J. Jin

Campbell University

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Journal of Medicinal Chemistry
Volume	53
DOIs	https://doi.org/10.1021/jm901543m
State	Published - Jan 1 2009

Disciplines

Pharmacy and Pharmaceutical Sciences

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10.1021/jm901543mLicense: Unspecified

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825141/

Cite this

Liu, F., Chen, X., Hassani, A. A., Quinn, A. M., Wasney, G. A., Dong, A., Barsyte, D., Kozieradzki, I., Senisterra, G., Chau, I., Kireev, D. B., Jadhav, A., Herold, J. M., Frye, S. V., Arrowsmith, C. H., Brown, P. J., Simeonov, A., Vedadi, M., & Jin, J. (2009). Discovery of a 2,4-Diamino-7-aminoalkoxy-quinazoline as a potent, selective, and cellularly active inhibitor of histone lysine methyltransferase G9a. Journal of Medicinal Chemistry, 53. https://doi.org/10.1021/jm901543m

Liu, F, Chen, X, Hassani, AA, Quinn, AM, Wasney, GA, Dong, A, Barsyte, D, Kozieradzki, I, Senisterra, G, Chau, I, Kireev, DB, Jadhav, A, Herold, JM, Frye, SV, Arrowsmith, CH, Brown, PJ, Simeonov, A, Vedadi, M & Jin, J 2009, 'Discovery of a 2,4-Diamino-7-aminoalkoxy-quinazoline as a potent, selective, and cellularly active inhibitor of histone lysine methyltransferase G9a', Journal of Medicinal Chemistry, vol. 53. https://doi.org/10.1021/jm901543m

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title = "Discovery of a 2,4-Diamino-7-aminoalkoxy-quinazoline as a potent, selective, and cellularly active inhibitor of histone lysine methyltransferase G9a",

author = "F. Liu and X. Chen and Hassani, \{A. A.\} and Quinn, \{A. M.\} and Wasney, \{G. A.\} and A. Dong and D. Barsyte and I. Kozieradzki and G. Senisterra and I. Chau and Kireev, \{D. B.\} and A. Jadhav and Herold, \{J. M.\} and Frye, \{S. V.\} and Arrowsmith, \{C. H.\} and Brown, \{P. J.\} and A. Simeonov and M. Vedadi and J. Jin",

year = "2009",

month = jan,

day = "1",

doi = "10.1021/jm901543m",

language = "American English",

volume = "53",

journal = "Journal of Medicinal Chemistry",

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TY - JOUR

T1 - Discovery of a 2,4-Diamino-7-aminoalkoxy-quinazoline as a potent, selective, and cellularly active inhibitor of histone lysine methyltransferase G9a

AU - Liu, F.

AU - Chen, X.

AU - Hassani, A. A.

AU - Quinn, A. M.

AU - Wasney, G. A.

AU - Dong, A.

AU - Barsyte, D.

AU - Kozieradzki, I.

AU - Senisterra, G.

AU - Chau, I.

AU - Kireev, D. B.

AU - Jadhav, A.

AU - Herold, J. M.

AU - Frye, S. V.

AU - Arrowsmith, C. H.

AU - Brown, P. J.

AU - Simeonov, A.

AU - Vedadi, M.

AU - Jin, J.

PY - 2009/1/1

Y1 - 2009/1/1

UR - https://cufind.campbell.edu/pharmacy/2312

UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825141/

U2 - 10.1021/jm901543m

DO - 10.1021/jm901543m

M3 - Article

VL - 53

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

ER -

Discovery of a 2,4-Diamino-7-aminoalkoxy-quinazoline as a potent, selective, and cellularly active inhibitor of histone lysine methyltransferase G9a

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