Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma

R. S. McNeill; D. A. Canoutas; T. J. Stuhlmiller; H. D. Dhruv; D. M. Irvin; R. E. Bash; S. P. Angus; L. E. Herring; J. M. Simon; K. R. Skinner; J. C. Limas; X. Chen; R. S. Schmid; M. B. Siegel; A. E. Van Swearingen; M. J. Hadler; E. P. Sulman; J. N. Sarkaria; C. K. Anders; L. M. Graves; M. E. Berens; G. L. Johnson; C. R. Miller

doi:10.1093/neuonc/nox044

Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma

R. S. McNeill, D. A. Canoutas, T. J. Stuhlmiller, H. D. Dhruv, D. M. Irvin, R. E. Bash, S. P. Angus, L. E. Herring, J. M. Simon, K. R. Skinner, J. C. Limas, X. Chen, R. S. Schmid, M. B. Siegel, A. E. Van Swearingen, M. J. Hadler, E. P. Sulman, J. N. Sarkaria, C. K. Anders, L. M. GravesM. E. Berens, G. L. Johnson, C. R. Miller

Campbell University

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Neuro-Oncology
Volume	19
DOIs	https://doi.org/10.1093/neuonc/nox044
State	Published - Jan 1 2017

Disciplines

Pharmacy and Pharmaceutical Sciences

Access to Document

10.1093/neuonc/nox044License: Unspecified

https://pubmed.ncbi.nlm.nih.gov/28379424/

Cite this

McNeill, R. S., Canoutas, D. A., Stuhlmiller, T. J., Dhruv, H. D., Irvin, D. M., Bash, R. E., Angus, S. P., Herring, L. E., Simon, J. M., Skinner, K. R., Limas, J. C., Chen, X., Schmid, R. S., Siegel, M. B., Van Swearingen, A. E., Hadler, M. J., Sulman, E. P., Sarkaria, J. N., Anders, C. K., ... Miller, C. R. (2017). Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma. Neuro-Oncology, 19. https://doi.org/10.1093/neuonc/nox044

McNeill, RS, Canoutas, DA, Stuhlmiller, TJ, Dhruv, HD, Irvin, DM, Bash, RE, Angus, SP, Herring, LE, Simon, JM, Skinner, KR, Limas, JC, Chen, X, Schmid, RS, Siegel, MB, Van Swearingen, AE, Hadler, MJ, Sulman, EP, Sarkaria, JN, Anders, CK, Graves, LM, Berens, ME, Johnson, GL & Miller, CR 2017, 'Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma', Neuro-Oncology, vol. 19. https://doi.org/10.1093/neuonc/nox044

@article{3325fa1b9f8f4e3c960035be66cc8e94,

title = "Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma",

author = "McNeill, \{R. S.\} and Canoutas, \{D. A.\} and Stuhlmiller, \{T. J.\} and Dhruv, \{H. D.\} and Irvin, \{D. M.\} and Bash, \{R. E.\} and Angus, \{S. P.\} and Herring, \{L. E.\} and Simon, \{J. M.\} and Skinner, \{K. R.\} and Limas, \{J. C.\} and X. Chen and Schmid, \{R. S.\} and Siegel, \{M. B.\} and \{Van Swearingen\}, \{A. E.\} and Hadler, \{M. J.\} and Sulman, \{E. P.\} and Sarkaria, \{J. N.\} and Anders, \{C. K.\} and Graves, \{L. M.\} and Berens, \{M. E.\} and Johnson, \{G. L.\} and Miller, \{C. R.\}",

year = "2017",

month = jan,

day = "1",

doi = "10.1093/neuonc/nox044",

language = "American English",

volume = "19",

journal = "Neuro-Oncology",

}

TY - JOUR

T1 - Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma

AU - McNeill, R. S.

AU - Canoutas, D. A.

AU - Stuhlmiller, T. J.

AU - Dhruv, H. D.

AU - Irvin, D. M.

AU - Bash, R. E.

AU - Angus, S. P.

AU - Herring, L. E.

AU - Simon, J. M.

AU - Skinner, K. R.

AU - Limas, J. C.

AU - Chen, X.

AU - Schmid, R. S.

AU - Siegel, M. B.

AU - Van Swearingen, A. E.

AU - Hadler, M. J.

AU - Sulman, E. P.

AU - Sarkaria, J. N.

AU - Anders, C. K.

AU - Graves, L. M.

AU - Berens, M. E.

AU - Johnson, G. L.

AU - Miller, C. R.

PY - 2017/1/1

Y1 - 2017/1/1

UR - https://cufind.campbell.edu/pharmacy/2328

UR - https://pubmed.ncbi.nlm.nih.gov/28379424/

U2 - 10.1093/neuonc/nox044

DO - 10.1093/neuonc/nox044

M3 - Article

VL - 19

JO - Neuro-Oncology

JF - Neuro-Oncology

ER -

Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma

Disciplines

Access to Document

Other files and links

Cite this