A First-in-Class Chemical-Induced Proximity System Achieves Dose-Dependent Control of Tumor Protein P53 Gene Activation in Preclinical Models of Gastric Cancer

Travis Nelson; R. M.  Kemper; A. M.  Chiarella; S. Gonzalez Tineo; M.  Carroll; S. Tripathi; B. J.  Clarke; X. Yu; X. Hu; A. J.  Cooke; B. Chirumamilla; A. Chandler; E. McGilvary; S. G. Pattenden; J. Jin; D. J.  Crona; N. A. Hathaway

doi:10.1021/acsptsci.5c00402

A First-in-Class Chemical-Induced Proximity System Achieves Dose-Dependent Control of Tumor Protein P53 Gene Activation in Preclinical Models of Gastric Cancer

Travis Nelson
, R. M. Kemper
, A. M. Chiarella
, S. Gonzalez Tineo
, M. Carroll
, S. Tripathi
, B. J. Clarke
, X. Yu
, X. Hu
, A. J. Cooke
, B. Chirumamilla
, A. Chandler
, E. McGilvary
, S. G. Pattenden
, J. Jin
, D. J. Crona
, N. A. Hathaway

Jerry M. Wallace School of Osteopathic Medicine

Research output: Contribution to journal › Article › peer-review

Original language	American English
Pages (from-to)	3585-3599
Journal	ACS Pharmacology and Translational Science
Volume	8
Issue number	10
DOIs	https://doi.org/10.1021/acsptsci.5c00402
State	Published - 2025

Access to Document

10.1021/acsptsci.5c00402

Cite this

Nelson, T., Kemper, R. M., Chiarella, A. M., Gonzalez Tineo, S., Carroll, M., Tripathi, S., Clarke, B. J., Yu, X., Hu, X., Cooke, A. J., Chirumamilla, B., Chandler, A., McGilvary, E., Pattenden, S. G., Jin, J., Crona, D. J., & Hathaway, N. A. (2025). A First-in-Class Chemical-Induced Proximity System Achieves Dose-Dependent Control of Tumor Protein P53 Gene Activation in Preclinical Models of Gastric Cancer. ACS Pharmacology and Translational Science, 8(10), 3585-3599. https://doi.org/10.1021/acsptsci.5c00402

A First-in-Class Chemical-Induced Proximity System Achieves Dose-Dependent Control of Tumor Protein P53 Gene Activation in Preclinical Models of Gastric Cancer. / Nelson, Travis; Kemper, R. M. ; Chiarella, A. M. et al.
In: ACS Pharmacology and Translational Science, Vol. 8, No. 10, 2025, p. 3585-3599.

Research output: Contribution to journal › Article › peer-review

Nelson, T, Kemper, RM, Chiarella, AM, Gonzalez Tineo, S, Carroll, M, Tripathi, S, Clarke, BJ, Yu, X, Hu, X, Cooke, AJ, Chirumamilla, B, Chandler, A, McGilvary, E, Pattenden, SG, Jin, J, Crona, DJ & Hathaway, NA 2025, 'A First-in-Class Chemical-Induced Proximity System Achieves Dose-Dependent Control of Tumor Protein P53 Gene Activation in Preclinical Models of Gastric Cancer', ACS Pharmacology and Translational Science, vol. 8, no. 10, pp. 3585-3599. https://doi.org/10.1021/acsptsci.5c00402

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author = "Travis Nelson and Kemper, \{R. M.\} and Chiarella, \{A. M.\} and \{Gonzalez Tineo\}, S. and M. Carroll and S. Tripathi and Clarke, \{B. J.\} and X. Yu and X. Hu and Cooke, \{A. J.\} and B. Chirumamilla and A. Chandler and E. McGilvary and Pattenden, \{S. G.\} and J. Jin and Crona, \{D. J.\} and Hathaway, \{N. A.\}",

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AU - Tripathi, S.

AU - Clarke, B. J.

AU - Yu, X.

AU - Hu, X.

AU - Cooke, A. J.

AU - Chirumamilla, B.

AU - Chandler, A.

AU - McGilvary, E.

AU - Pattenden, S. G.

AU - Jin, J.

AU - Crona, D. J.

AU - Hathaway, N. A.

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